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Креатинин в современной оценке функционального состояния почек (обзор литературы и собственные данные)

https://doi.org/10.36485/1561-6274-2020-24-4-21-36

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Аннотация

Скорость клубочковой фильтрации (СКФ) является общепризнанным показателем функционального состояния почек. В медицинской практике существуют различные подходы для измерения СКФ. Однако, несмотря на почти столетнюю историю, далеко не все методологические проблемы оценки СКФ в клинической практике решены. Наиболее физиологически обоснованные («референтные») методы неприемлемы в рутинной практике из-за сложности и дороговизны. Клиницистам приходится опираться в основном на результаты суррогатных способов, большинство из которых в качестве гломерулотропного тест-агента предполагают использование эндогенного креатинина. Поэтому точность определения концентрации этого метаболита в биологических средах (особенно в сыворотке крови) зачастую решающим образом определяет надежность оценки СКФ. Производители наборов реагентов для определения креатинина должны принимать во внимание современные требования к точности и прослеживаемости результатов измерений и обеспечивать соответствие своей продукции международным нормам.

Об авторах

И. Г. Каюков
Научно-исследовательский институт нефрологии, Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Россия

Проф. Каюков Иван Глебович, д-р мед. наук
197022, Санкт-Петербург, ул. Л. Толстого, д. 17. 

Тел.: 8(981)8153949



О. В. Галкина
Научно-исследовательский институт нефрологии, Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Россия

Галкина Ольга Владимировна, канд. биол. наук, лаборатория биохимического гомеостаза.

197022, Санкт-Петербург, ул. Л. Толстого, д. 17. 

Тел.: (812)3386901



Е. И. Тимшина
Общество с ограниченной ответственностью «Научно-производственная фирма «АБРИС+»
Россия

Тимшина Евгения Ивановна, биохимик-технолог

196006, Санкт-Петербург, ул. Цветочная, д. 16, лит. М, 2-й этаж

Тел.: 8(921)4019054



И. М. Зубина
Научно-исследовательский институт нефрологии, Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Россия

Зубина Ирина Михайловна, канд. биол. наук

197022, Санкт-Петербург, ул. Л. Толстого, д. 17. 

Тел.: (812)3386901



А.. Ю. Михеева
Химико-аналитический центр «Арбитраж», Всероссийский научно-исследовательский институт метрологии им. Д.И. Менделеева
Россия

Михеева Алена Юрьевна, канд. хим. наук, Научно-исследовательский отдел государственных эталонов в области органического и неорганического анализа, ведущий научный сотрудник

190005, Санкт-Петербург, Московский пр., д. 19. 

Тел.: 8(911)2507022



Г. М. Бердичевский
Химико-аналитический центр «Арбитраж», Всероссийский научно-исследовательский институт метрологии им. Д.И. Менделеева
Россия

Бердичевский Григорий Михайлович, Научно-исследовательский отдел государственных эталонов в области органического и неорганического анализа, инженер 2-й категории.

190005, Санкт-Петербург, Московский пр., д. 19. 

Тел.: 8(812)-2517601



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Для цитирования:


Каюков И.Г., Галкина О.В., Тимшина Е.И., Зубина И.М., Михеева А.Ю., Бердичевский Г.М. Креатинин в современной оценке функционального состояния почек (обзор литературы и собственные данные). Нефрология. 2020;24(4):21-36. https://doi.org/10.36485/1561-6274-2020-24-4-21-36

For citation:


Kayukov I.G., Galkina O.V., Timshina E.I., Zubina I.M., Miheeva A.U., Berdichevsky G.M. Creatinin in the modern evaluation of the kidneys functional condition (literature review and own data). Nephrology (Saint-Petersburg). 2020;24(4):21-36. (In Russ.) https://doi.org/10.36485/1561-6274-2020-24-4-21-36

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