A CASE OF LEFT-SIDED OCCLUSION OF THE RENAL ARTERY IN A CHILD WITH A GENETIC FORM OF THROMBOPHILIA
https://doi.org/10.24884/1561-6274-2017-21-1-95-100
Abstract
Recently has greatly improved diagnosis of hereditary thrombophilia. Unlike other forms of methylene tetrahydro folate reduktase gene mutation (MTHFR) that are characteristic of both venous and arterial thrombosis. In the literature described isolated cases of thrombosis of renal vessels in adults. The authors describe their own observation of a child with a congenital heart defect, who inherited thrombophilia manifested by the development of left-sided occlusion of the renal artery, resulting in severe renovascular hypertension and nephrosclerosis of left kidney. The girl on molecular genetic testing revealed a homozygous carrier of the plasminogen I type inhibitor allele, compound heterozygous allele carriers of MTHFR, heterozygous carrier of the methionine synthase reductase (MTRR) allele.
About the Authors
A. Ni
Pacific state medical University
Russian Federation
Russian Federation
Prof.Antonina Ni MD, PhD, DMedSci.
Department of Pediatric.
690990, Russia,Vladivostok, Ostraykova st., 2
T. A. Shumatova
Pacific state medical University
Russian Federation
Russian Federation
Prof. Tatyana A. Shumatova MD, PhD, DMedSci.
Department of Pediatric.
690990, Russia,Vladivostok, Ostraykova st., 2
V. N. Luchaninova
Pacific state medical University
Russian Federation
Russian Federation
Prof. Valentina N. Luchaninova MD, PhD, DMedSci.
Department of Pediatric.
690990, Russia,Vladivostok, Ostraykova st., 2
E. V. Grivkova
Regional clinical center of specialized types of medical care
Russian Federation
Russian Federation
Ekaterina Grivkova, Department of Pediatric cardiology and cardiovascular surgery.
690091, Russia,Vladivostok, Uborevicha st., 30/37.
O. V. Semeshina
Regional children’s clinical hospital No. 1,
Russian Federation
Russian Federation
Olga Semeshina MD, PhD,
Department of Nephrology.
Department of Nephrology.
References
1. Алексеев НА. Геморрагические диатезы и тромбофилии. Гиппократ, СПб., 2005; 516–556 [Alekseev NA. Gemoragicheskie diatezy i trombofilii. Gipokrat, SPb., 2005; 516-556]
2. Nowak-Gottl U, Duering C, Kempf-Bielack B, Strater R. Thromboembolic diseases in neonates and children. Pathophysiol Haemost Thromb 2004; 33: 269–274
3. Перепелкина АЕ, Орловская ИВ, Евтеева НВ, Рюмина ИИ. Диагностика и лечение внутрисердечных тромбов у новорожденных детей с наследственной гематогенной тромбофилией. Акуш и гин 2011; (6): 129-132 [Perepelkina AE, Orlovskaya IV, Evteeva NV, Ryumina II. Diagnostika i lechenie vnutriserdechnykh trombov u novorozhdenyhh detei s nasledstvenoi trombofiliei. Akusherstvo i ginekologiya 2011; (6): 129-132]
4. Monagle P, Adams M, Mahoney M et al. Outcome of pediatric thromboembolic disease: a report from the Canadian Childhood Thrombophilia Registry. Pediatr Res 2000; 47: 763–766
5. Козловская НЛ, Котлярова ГВ, Боброва ЛА, Сафонов ВВ. Двусторонняя окклюзия почечных артерий с восстановлением функции почек после длительной терапии программным гемодиализом у пациента с генетической формой тромбофилии. Нефрология и диализ 2008; (2): 151–159 [Kozlovskaya NL,Kotlyarova GV, Bobrova LA, Saphonov VV. Dvustoronyaya oklyuziya pochechnykh arteriy s vostanovleniem funkcii pochek posle dlitelnoi terapii programnym gemodializom u patsienta s geneticheskoi formoi tromdofilii. Nefrologiya i dializ 2008; (2): 151-159]
6. Raife TJ, Lentz SR, Atkinson BS et al. Factor V Leiden: a genetic risk factor for thrombotic microangiopathy in patients with normal von Willebrand factor-cleaving protease activity. Blood 2002; 99: 437-442
Review
For citations:
Ni A., Shumatova T.A., Luchaninova V.N., Grivkova E.V., Semeshina O.V. A CASE OF LEFT-SIDED OCCLUSION OF THE RENAL ARTERY IN A CHILD WITH A GENETIC FORM OF THROMBOPHILIA. Nephrology (Saint-Petersburg). 2017;21(1):95-100. (In Russ.) https://doi.org/10.24884/1561-6274-2017-21-1-95-100
Views:
2386
Email this article 