Features of the course steroid-sensitive nephrotic syndrome in children, infected and uninfected with mycobacterium tuberculosis

Abstract

AIM OF STUDY. To identify the features of the course steroid-sensitive nephrotic syndrome (NS) in children, infected and uninfected with Mycobacterium tuberculosis (MBT). PATIENTS AND METHODS. The study included 40 patients in the age from 1 to 17 years old with steroid-sensitive NS treated with corticosteroids and cytostatic therapy with a preserved renal function. During the study used the catamnesis, clinical - laboratory, immunological, ELISA (defining general and specific IgE) methods, performed tuberculosis clinical minimum (identification of contact with TB patients, information about BCG vaccination, Mantoux test, chest radiography, urine for MBT). RESULTS. Among 40 children with NS in 5 diagnosed post-vaccination allergy, in 2 -infection with MBT previous years (more than 1 year). The outcome of the NS in 7 children with post-vaccination allergy and tuberculosis infection in complete remission as a result of, corticosteroid(6) and cytostatic(1) therapy. CONCLUSION. In children with steroid-sensitive NS identified post-vaccination allergy in 12.5%, infection with MBT to 5%. In children with tuberculosis infection NS is characterized by frequently relapsing (p <0.05).