MORPHOLOGICAL ADAPTATION-COMPENSATORY CHANGES DYNAMICS IN CONTRALATERAL KIDNEY DURING URETERAL OBSTRUCTION IN THE EXPERIMENT
https://doi.org/10.24884/1561-6274-2017-21-5-119-124
Abstract
THE AIM was to study morphological changes in the contralateral kidney in the dynamics of obstructive uropathy development.
MATERIAL AND METHODS. Morphological examination of the contralateral kidney with obstructive uropathy on days 7, 14 and 21 revealed a number of characteristic structural changes in the tubular apparatus and interstitial substance.
RESULTS. During the first 7 days of obstruction development, dystrophic changes predominated due to disturbance of waterelectrolyte, protein metabolism (hyaline-droplet, hydrophilic dystrophy of the tubular apparatus), after 14-21 days changes occurred in the stroma of the renal tissue. It should be noted the emergence in these terms of the so-called mesh fibrosis, localized between individual tubular structures of the medulla of the kidney with following the development of neoangiogenesis in it.
Conclusion. The described morphofunctional patterns of changes in the contralateral kidney in experimental obstructive uropathy will give an idea of not only the severity of water-electrolyte disorders but also the timing of early development of fibrosis and neoangiogenesis of the renal parenchyma.
About the Authors
M. A. Akimenko
Rostov State Medical University
Russian Federation
Russian Federation
Department of Medical Biology and Genetics,
344022, Rostov-on-Don, Nahichevansky av., 29
S. S. Todorov
Rostov State Medical University
Russian Federation
Russian Federation
M.D., PhD, DMedSci, head of the morphological department and department of molecular biological and optical methods of research,
344022, Rostov-on-Don, Nahichevansky av., 29
T. S. Kolmakova
Rostov State Medical University
Russian Federation
Russian Federation
Assosiate professor, PhD, DBiolSci, Department of Medical Biology and Genetics, head,
344022, Rostov-on-Don, Nahichevansky av., 29
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Review
For citations:
Akimenko M.A., Todorov S.S., Kolmakova T.S. MORPHOLOGICAL ADAPTATION-COMPENSATORY CHANGES DYNAMICS IN CONTRALATERAL KIDNEY DURING URETERAL OBSTRUCTION IN THE EXPERIMENT. Nephrology (Saint-Petersburg). 2017;21(5):80-84. (In Russ.) https://doi.org/10.24884/1561-6274-2017-21-5-119-124
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