FREQUENCY AND CHARACTER OF COMBINED CONGENITAL ANOMALY OF KIDNEYS AND URINARY TRACT IN STRUCTURE CAKUT-SYNDROME IN CHILDREN
https://doi.org/10.24884/1561-6274-2018-22-3-51-57
Abstract
THE AIM. Identify the frequency and nature of the combined congenital anomaly of kidney and urinary tract development in the structure of isolated and syndromic CAKUT syndrome in 100 children. PATIENTS AND METHODS. 100 children (57 boys and 43 girls) with CAKUT syndrome, aged 2 months to 17 years, were examined. RESULTS. Out of 100 patients, 94% were isolated and 6% had syndrome CAKUT syndrome. Stratification of stage of CKD C1–5 was performed taking into account the glomerular filtration rate in 85 children with CAKUT (aged 2–17 years), the predominance С1 (74%).
About the Authors
I. Kutyrlo
Saint-Petersburg Pediatric State Medical University
Russian Federation
Russian Federation
N. Savenkova
Saint-Petersburg Pediatric State Medical University
Russian Federation
Russian Federation
References
1. Ignatova M. S. Dizehmbiogenez organov mochevoj sistemy i nefropatii. Detskaya nefrologiya. Pod red. M. S. Ignatovoj. 2011; 10–15
2. Papayan AV, Savenkova ND. Klinicheskaya nefrologiya detskogo vozrasta. «Levsha. Sankt-Peterburg», SPb., 2008; 600
3. Ignatova M.S. CAKUT-syndrom u detei. Pedaitria 2012; 91(6):141–144
4. Kutyrlo IE, Savenkova ND. CAKUT-syndrom u detei. Nephrologia 2017;21(3):18–24
5. Vivante A, Kohl S, Hwang DY et al. Single-gene causes of congenital anomalies of the kidney and urinary tract (CAKUT) in humans. Pediatr Nephrol 2014; (29): 695–704
6. Lopatkin N. A. Anomalii razvitiya pochek, mochevyih putey i muzhskih polovyih organov. V: Urologiya. «Meditsina», М., 2013; 147–210
7. Renkema KJ, Winyard PY, Skovorodkin IN, et al. Congenital anomalies of the kidney and urinary tract (CAKUT). Nephrol Dual Transplant 2012; 8 (12): 3842–3851
8. Nicolaou N, Renkema KY, Bongers EM et all. Genetic, environmental, and epigenetic factors involved in CAKUT. Nat Rev Nephrol 2015;11(12):720–731
9. Danziger P, Berman DR, Luckritz K et al. Severe congenital anomalies of the kidney and urinary tract: epidemiology can inform ethical decision-making. J Perinatology 2016; 36: 954–959
10. Dlin V.V., Osmanov I.M., Chugunova O.L. Infekciya mochevoy sistemyi u detei. «Overley», М., 2017; 422
11. K/DOOQ, Clinical Practice Guidelines for Chronic Kidney Disease: Evaluation Classification Stratification. Am J Kidney Dis 2002; 39 (2 Suppl. 1): 1–266
12. Hogg RJ, Furth S, Lemley KV et al. National Kidney Foundation’s KidneyDisease Outcomes Quality Initiative clinical practice guidelines for chronic kidney disease in children and adolescents: evaluation, classification, and stratification. Pediatrics 2003;111:1416–1421
13. Schnaper H.W/ Patophysiology of prigressive Renal Diasease in Children. Pediatric Nephrology. Eds: Avner E.D., Harmon W.E., Niaudet P, Yoshikawa N. 7 Completely Revised, Update and Enlerge Edition, Vol2, Springer-Verlag Berlin Heidelberg. 2016; 2171–2207
14. Smirnov AV, SHilov EM, Dobronravov VA i dr. Nacional’nye rekomendacii. Hronicheskaya bolezn’ pochek: osnovnye principy skrininga, diagnostiki, profilaktiki i podhody k lecheniyu. «Levsha», Sankt-Peterburg, 2012; 54
15. Laglois V. Laboratory Evalution at Different Ages. In: Comprehensive pediatric nephrology. Eds. D.F. Geary, F. Schaefer Mosby Elsevier, Philadelphia. 2008; 39–54
16. Stoll C, Dott B, Alembik Y, Roth MP. Associated nonurinary congenital anomalies among infants with congenital anomalies of kidney and urinary tract (CAKUT). Eur J Med Genet 2014; 57(7):322–328
17. Leviashvili ZhG, Savenkova ND, Anichkova IV. Оsobennosti patologii pochek u detey s Lowe sindromom. Nefrologiya 2015; 19 (6): 53–60
18. Renkema KJ, Winpred PJ, Scovorodkin IN et al. Nonel Perspectives for undestending congenital anomalies of the kidney and urinary tract (CAKUT). Nephrol dial Transplant 2011; 26(14): 3841–3851
19. Ishikura К, Uemura O, Hamasaki Y et al. Insignificant impact of VUR on the progression of CKD in children with CAKUT. Pediatr Nephrol 2016; 31:105–112
20. Harambat J, van Stalen KJ, Kim JJ et al. Epidemiology of chronic kidney diseases. Pediatr Nephrol 2012; 27(3): 363–373
21. Lysova EV, Savenkova ND. Chastota CAKUT-sindroma v ehtiologicheskoj strukture hronicheskoj bolezni pochek u detej i podrostkov. Ross vest perinatol pediatr 2016; 61: 212–213
22. Cordell H, Darlay R, Charoen P et al. Whole-Genome Linkage and Association Scan in Primary, Non synndromatic Vesicoureteral Reflux. J Am Soc Nephrol 2010; 21(1):113–123
23. Vailkova AA. Chronicheskay bolezn pochek. Orenburgskiy med vestnik 2015; 42–51
24. Vjalkova AA. Sovremennoe predstavlenie o tubulointersticial’nyh nefropatijah i koncepcija hronicheskoj bolezni pochek v prakticheskoj nefrologii. Pediatrija 2008; 129–131
Review
For citations:
Kutyrlo I., Savenkova N. FREQUENCY AND CHARACTER OF COMBINED CONGENITAL ANOMALY OF KIDNEYS AND URINARY TRACT IN STRUCTURE CAKUT-SYNDROME IN CHILDREN. Nephrology (Saint-Petersburg). 2018;22(3):51-57. (In Russ.) https://doi.org/10.24884/1561-6274-2018-22-3-51-57
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