REPRODUCTIVE HEALTH OF PATIENTS WITH HORMONE SENSITIVE NEPHROTIC SYNDROME WITH PREDNISOLONE AND CYTOSTATICS TREATMENT

Abstract

THE AIM. Assess the impact of glucocorticoid and cytostatic therapy on the formation of the reproductive system in girls and reproductive status of women with the nephrotic syndrome with minimal changes (NSMC). PATIENTS AND METHODS. The reproductive health in 30 patients with NSMC in age from 14 to 35 years, who received glucocorticoid (GPC) and cytostatic therapy (CS) were discussed. RESULTS. The evaluation showed that the sequence of development of secondary sexual characteristics is not impaired in 30 patients. A total score of sexual development (according L.G. Tumilovich) in the group of patients with NSMC was 11,92 ± 0,4 sexual development appropriate to the age. Among the 28 patients who were examined in stable remission for 233 years, regular menstrual cycles occurred in 100%. In patients with NSMC in 1 case observed disruption of the menstrual cycle on a background of prolonged GPC and in 2 cases mentioned menstrual disorders by type opsomenoreya against cytostatic therapy. Of the 21 patients of childbearing age with a stable remission NSMC, 8 reported normal ran through pregnancy and childbirth, culminating in the birth of live fullterm infants with no relapse of nephrotic syndrome. CONCLUSION. The use of GPC
in hormone sensitive NS in a neutral period does not lead to violations of sexual development and menstrual function. In women of childbearing age with a stable remission of the National Assembly, received GPC and CS therapy in childhood, are registered properly flowed pregnancy and childbirth, the birth of live fullterm infants with no recurrence of the National Assembly.