TO THE PROBLEM OF THE ESTIMATION OF THE GLOMERULAR FILTRATION RATE AT PATIENTS WITH CHRONIC KIDNEY DISEASE
https://doi.org/10.24884/1561-6274-2011-15-1-104-110
Abstract
THE AIM. Comparison of values of the glomerular filtration rate (GFR), received by a referential method (a plasmatic clearance 99mTcDTPA GFRDTPA) with results of determination of the given parameter on a creatinine clearance (CСr), to equations MCQ (eGFRMCQ), CKDEPI (eGFREPI), MDRD7 (eGFRMDRD) and formula D.W. Cockcroft, M.H. Gault (CCG) at patients of chronic kidney disease (CKD). PATIENTS AND METHODS. 98 patients with CKD with value eGFRMDRD ≥90 (n=18); ≥60 <90 (n=30), ≥30 <60 (n=33) and <30 (n=17) ml/min/1.73 m2 are investigated. At all the parameters specified above are defined. All patients were inhabitants of St.Petersburg (Russia) and belonged to Caucasian race. RESULTS. In whole group average value GFRDTPA (71.9±2.7) was significantly more low, than CСr (84.3±3.7; P <0.0001), eGFRMCQ (77.6±3.5; P=0.006) and CCG (78.2±3.7; P=0.026), but significantly higher, than eGFRMDRD (60.0±2.7; P = <0.0001) and eGFREPI (64.8±2.8; P <0.0002). In the general group highly significant direct correlation between GFRDTPA and all other estimations GFR (Pirson’s linear correlation coefficient from 0.67 to 0.82; P <0.0001 in all cases) took place. At the same time in the separate studied ranges conformity between GFRDTPA and all other estimations GFR has appeared not satisfactory. CONCLUSION. The obtained results, specifies in necessity of working out of ways of determination eGFR, adapted for features of concrete population.
About the Authors
R. T. NAUEL
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Russian Federation
Russian Federation
O. A. DEGTEREVA
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Russian Federation
Russian Federation
I. G. KAYUKOV
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Russian Federation
Russian Federation
V. A. DOBRONRAVOV
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Russian Federation
Russian Federation
A. G. KUCHER
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Russian Federation
Russian Federation
Yu. A. NIKOGOSYAN
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Russian Federation
Russian Federation
L. N. KUKOLEVA
Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова
Russian Federation
Russian Federation
References
1. National Kidney Foundation KD: Clinical practice guidelines for chronic Kidney disease: Evaluation, classification and stratification. Am J Kidney Dis 2002;39 [Suppl 1]: S1-S266
2. Смирнов АВ, Есаян АМ, Каюков ИГ. Хроническая болезнь почек: на пути к единству представлений. Нефрология 2002; 6(4): 11-17
3. Смирнов АВ, Каюков ИГ, Есаян АМ и др. Превентивный подход в современной нефрологии. Нефрология 2004;8(3): 7-14
4. Levey AS, Eckardt KU, Tsukamoto Y et al. Definition and classification of chronic kidney disease: a position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int 2005; 67(6): 2089-20100
5. Смирнов АВ, Добронравов ВА, Каюков ИГ, Есаян АМ.Хроническая болезнь почек: дальнейшее развитие концепции и классификации. Нефрология 2007; 11(4): 7-17
6. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976;16(1): 31-41
7. Levey AS, Bosch JP, Lewis JB. A more accurate method to estimate glomerular filtration rate from serum creatinine; a new prediction equation. Ann Intern Med 1999;130(8): 461-470
8. Levey AS, Greene T, Kusek JW, Beck GJ. A simplified equation to predict glomerular filtration rate from serum creatinine. J Am Soc Nephrol 2000; 11: A0828
9. Ibrahim S, Rashid L, Darai M. Modification of diet in renal disease equation underestimates glomerular filtration rate in egyptian kidney donors. Exp Clin Transplant 2008; 6(2):144-148
10. Ma YC, Zuo L, Chen JH et al. Modified glomerular filtration rate estimating equation for Chinese patients with chronic kidney disease. J Am Soc Nephrol 2006;17(10): 2937- 2944
11. Hallan S, Asberg A, Lindberg M, Johnsen H. Validation of the Modification of Diet in Renal Disease formula for estimating GFR with special emphasis on calibration of the serum creatinine assay. Am J Kidney Dis 2004; 44(1): 84-93
12. Levey AS, Stevens LA, Schmid CH et al. A new equation to estimate glomerular filtration rate. Ann Intern Med 2009;150: 604-612
13. Delanaye P, Cavalier E, Mariat C et al. MDRD or CKD-EPI study equations for estimating prevalence of stage 3 CKD in epidemiological studies: which difference? Is this difference relevant? BMC Nephrol 2010;11: 8. Published online 2010 June 1. doi: 10.1186/1471-2369-11-8
14. Rule AD, Larson TS, Bergstralh EJ et al. Using serum creatinine to estimate glomerular filtration rate: accuracy in good health and in chronic kidney disease. Ann Intern Med 2004;141: 929–937
15. Beauvieux MC, Le Moigne F, Lasseur C et al. New predictive equations improve monitoring of kidney function in patients with diabetes. Diabetes Care 2007; 30(8):1988-1994
16. Matsuo S, Imai E, Horio M et al. Revised equations for estimated GFR from serum creatinine in Japan. Am J Kidney Dis 2009;53(6):982-992
17. Blaufox MD, Aurell M, Bubeck B et al. Report of the Radionuclides in Nephrourology Committee on renal clearance. J Nucl Med 1996; 7(11): 1883-1890
18. Stevens LA, Coresh J, Greene T, Levey AS. Assessing kidney function-measured and estimated glomerular filtration rate. N Engl J Med 2006; 354: 2473-2483
19. European Best Practice Guidelines, Expert Group on Hemodialysis, European Renal Association. Section I. Measurement of renal function, when to refer and when to start dialysis. Nephrol Dial Transplant 2002; 17 [suppl 7]; 7-15
20. Rodrigo E, de Francisco AL, Escallada R et al. Measurement of renal function in pre-ESRD patients. Kidney Int 2002; 61[suppl 80]: S11-S17
21. Gehan E, George SL. Estimation of human body surface area from height and weight. Cancer Chemother Rep 1970; 54: 225-235
Review
For citations:
NAUEL R.T., DEGTEREVA O.A., KAYUKOV I.G., DOBRONRAVOV V.A., KUCHER A.G., NIKOGOSYAN Yu.A., KUKOLEVA L.N. TO THE PROBLEM OF THE ESTIMATION OF THE GLOMERULAR FILTRATION RATE AT PATIENTS WITH CHRONIC KIDNEY DISEASE. Nephrology (Saint-Petersburg). 2011;15(1):104-110. (In Russ.) https://doi.org/10.24884/1561-6274-2011-15-1-104-110
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