THE ROLE OF KETOSTERIL IN NEPHROPROTECTION AND CARDIOPROTECION IN EXPERIMENTAL UREMIA

THE AIM of the work was to study the influence of lowprotein diet (LPD) with added ketosteril on biochemical indices of blood serum, arterial pressure, hypertrophy of the left ventricle myocardium of rats with experimental uremia. MATERIAL AND METHODS. The investigation was fulfilled in male Wistar rats subjected to 5/6 nephrectomy (NE). In two weeks after NE one group of the animals was given a standard diet (20.16% of animal protein), the other group was given a diet containing 10% ketosteril and 90% vegetable food. The control group contained sham-operated rats receiving a standard diet. RESULTS. The diet containing ketosteril was found to reduce the degree of uremia, phosphatemia, and prevents the development of hypocalcemia in rats with NE. In the animals given ketosteril the average arterial pressure and heart rate in 2 months after NE were not higher than those of control animals. Hypertrophy of the heart left ventricle was less pronounced than in the rats with NE given a standard diet. CONCLUSION. The results obtained confirm the fact of renoprotective effects of LPD with ketosteril. The data on cardioprotective influence of the diet including ketosteril are thought to be an additional ground in favor of expedience to use the substance in nephrological practice.

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