THE CORRECTION OF FUNCTION AND MICROCIRCULATION DISTURBANCES OF RENAL ALLOGRAFTS WITH PLASMAPHERESIS IN EARLY POSTOPERATIVE PERIOD

THE AIM: to study the effect of plasmapheresis on the initial function and intraorganic blood flow of renal graft in the early postoperative period. PATIENTS AND METHODS: we evaluated the results of treatment of 60 renal transplant recipients. The patients were divided into two groups: in 30 recipients of group 1 we applied plasmapheresis with replacement from 1,4 to 3,7 liters of plasma and in 30 recipients of control group we have not performed plasmapheresis. RESULTS: intraorganic hemodynamics clearly reflects the functional state of the transplanted kidney. High resistive index (Ri> 0,9) is an informative diagnosis criterion of acute tubular necrosis and it’s also indicates an inadequate blood supply to the kidneys. Plasmapheresis has expressed positive effect on renal hemodynamics, initial graft function, glomerular filtration rate, the duration of azotemia normalization period. Immediate graft function in patients of group 1 was observed in 26 patients, whereas in the group 2 – only in 14. There were no patients with initial non-functioning graft in group 1, while in group 2 there were two such patients. CONCLUSION: plasmapheresis performed in the early postoperative period (not later than 3-5 hours after reperfusion of the graft) has an expressed positive effect on the functional state of the transplanted kidney.

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