CLINICAL AND MOTPHOLOGIVAL ANALYSIS OF CHANGES OF PERITUBULAR MICROCIRCULATION VESSELS OF FIDNEY INTERSTITIAL TISSUE IN PATIENTS WITH IGA-NEPHROPATHY (IGAN) WITH ESTIMATION OF LECTIN PATHWAY OF COMPLEMENT ACTIVATION
https://doi.org/10.24884/1561-6274-2013-17-4-89-94
Abstract
The study of a group of patients with IgA-nephropathy (IgAN ) was performed with detailed analysis of inflammatory and sclerotic changes in the tubuloinetrstitium (TIN). As well as immunohistochemical analysis of activity C4d – MBL activation marker of complement pathway. Quantitively and and semiquantitatively were estimated immunoglobulins (IgG, IgM, IgM), complement fractions C1q, C3c, fibrinogen, kappa light chains and lambda deposition, the number of TIN microvessels with – C4d – positive reaction in endothelium. Extracapillary proliferation, global and segmental sclerosis, mesangial proliferation, interstitial fibrosis, the number of peritubular capillaries in the TIN with leukocytes-peritubular capillaritis (PTC), the age, sex, daily proteinuria and serum creatinine, glomerular filtration rate (GFR) by MDRD were evaluated. As a result we have obtained the data about inflammatory activity in TIN microvessels of some patients under IgAN that may signify the partial activation the lectin complement pathway and the more severe clinical course.
About the Authors
V. G. Sipovskyi
НИИ нефрологии, Санкт-Петербургский государственный медицинский университет им. акад. И.П.Павлова
Russian Federation
Russian Federation
V. A. Dobronravov
НИИ нефрологии, Санкт-Петербургский государственный медицинский университет им. акад. И.П.Павлова
Russian Federation
Russian Federation
A. V. Karunnaya
НИИ нефрологии, Санкт-Петербургский государственный медицинский университет им. акад. И.П.Павлова
Russian Federation
Russian Federation
A. V. Smirnov
НИИ нефрологии, Санкт-Петербургский государственный медицинский университет им. акад. И.П.Павлова
Russian Federation
Russian Federation
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Review
For citations:
Sipovskyi V.G., Dobronravov V.A., Karunnaya A.V., Smirnov A.V. CLINICAL AND MOTPHOLOGIVAL ANALYSIS OF CHANGES OF PERITUBULAR MICROCIRCULATION VESSELS OF FIDNEY INTERSTITIAL TISSUE IN PATIENTS WITH IGA-NEPHROPATHY (IGAN) WITH ESTIMATION OF LECTIN PATHWAY OF COMPLEMENT ACTIVATION. Nephrology (Saint-Petersburg). 2013;17(4):89-94. (In Russ.) https://doi.org/10.24884/1561-6274-2013-17-4-89-94
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