USING OF NEW MARKER OF GLOMERULAR FILTRATION RATE EVALUATION – CYSTATIN C IN PEDIATRIC PATIENTS
https://doi.org/10.24884/1561-6274-2013-17-3-75-79
Abstract
This article discusses the possibility of using a new marker for the determination of renal function in pediatric patients - cystatin C. AIM OF STUDY: to determine the glomerular filtration rate using different methods of creatinine, as well as a new marker of kidney injury - cystatin C in children. PATIENTS AND METHODS: 83 patients from 1 month to 17 years (mean age 4,15 ± 5,08 years) with various nephropathies were examined. RESULTS: were determined the serum concentration of cystatin C (1,3 ± 0,38 mg/l), creatinine (0,62 ± 0,72 mg%) and glomerular filtration rate (GFR) using formulas based on creatinine and cystatin C. We conducted a comparative analysis of glomerular filtration with different methods of study. CONCLUSION: The serum concentration of cystatin C is independent of sex, and its higher level is determined in the first year of life. The most important for practical use in pediatrics are formulas using cystatin C and creatinine.
About the Authors
V. P. Sitnikova
ГБОУ ВПО «Воронежская государственная медицинская академия им. Н.Н. Бурденко» Минздрава России
Russian Federation
Russian Federation
Y. V. Pashkova
ГБОУ ВПО «Воронежская государственная медицинская академия им. Н.Н. Бурденко» Минздрава России
Russian Federation
Russian Federation
I. N. Popova
Воронежская областная детская клиническая больница №1
Russian Federation
Russian Federation
References
1. Каюков ИГ, Смирнов АВ, Эмануэль ВЛ. Цистатин в современной медицине. Нефрология 2012;16(1):22-39
2. Grubb A. Non-invasive estimation of glomerular filtration rate (GFR). The Lund model: Simultaneous use of cystatin C- and creatinine-based GFR-prediction equations, clinical data and an internal quality check. Scand J Clin Lab Invest 2010;70(2):65-70
3. Комарова ОВ, Цыгин АН, Кучеренко АГ, Смирнов ИЕ. Цистатин С как маркер почечных функций у детей с ХБП. Нефрология и диализ 2010;12(4):272-276
4. Клиническая нефрология детского возраста. Руководство для врачей, под ред. А.В. Папаяна, Н.Д. Савенковой. Левша. Санкт-Петербург, СПб, 2008; 600
5. Арутюнов ГП, Оганезова ЛГ. Часто задаваемые вопросы о скорости клубочковой фильтрации. Клиническая нефрология 2009;3:35-42
6. Черканова МС, Короленко ТА, Филатова ТГ, Бравве ИЮ. Эндогенный ингибитор цистеиновых протеаз цистатин С как предиктор развития атеросклероза и изменения при операции коронарного шунтирования. Бюллетень СО РАМН 2007;125(3):133-137
7. Комарова OB, Цыгин АН, Кучеренко АГ, Смирнов ИЕ. Цистатин С как маркер почечных функций у детей с ХБП. Нефрология и диализ 2010;12(4)272-276
8. Filler G. Cystatin C as a marker of GFR – history, indications, and future research. Clin Biochem 2005;38 (1):1-8
9. Schwartz GJ, Haycock GB, Edelmann Jr, Spitzer A. A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics1976;58:259–263
10. Counahan R, Chantler C, Ghazali S, Kirkwood B, Rose F, Barratt TM. Estimation of glomerular filtration rate from plasma creatinine concentration in children. R. Arch Intern Med 1976;(51)875–878
11. Léger F., F, Y. Coulais, Tafani M, Chatelut E. Estimation of glomerular filtration rate in children. Pediatr Nephrol 2002;17: 903-907
12. Grubb A, Nyman U, Björk J, Lindström V, Rippe B, Sterner G, Christensson A. Simple cystatin C-based prediction equations for glomerular filtration rate compared with the modification of diet in renal disease prediction equation for adults and the Schwartz and the Counahan-Barratt prediction equations for children. Clin Chem 2005; 51(8):1420-1431
13. Zappitelli M, Parvex P, Joseph L, Paradis G, V. Grey G, Lau S, Bell L. Derivation and validation of cystatin C–based prediction equations for GFR in children. Am J Kidney Dis 2006;48:221-230
14. Filler G, Lepage N. Should the Schwartz formula for estimation of GFR be replaced by cystatin C formula? Pediatr Nephrol 2003;18:981-985
15. Bokenkamp А, Domanetzki M, Zinck R, Schumann G, Byrd D, Brodehl J. Cystatin C serum concentrations underestimate glomerular filtration rate in renal transplant recipients. Clin Chem 1999; 45(10):1866-1868
16. Larsson А, Scand J, Malm J, Grubb A, Hansson L. Calculation of glomerular filtration rate expressed in mL/min from plasma cystatin C values in mg/L . Clin Lab Invest 2004; 64:25-30
17. Bouvet YannY, Bouissou FF, Coulais YY, Séronie-Vivien SS. GFR is better estimated by considering both serum cystatin C and creatinine levels. Pediatr Nephrol 2006;21(9):1299-1306
18. Schwartz GJ, Munoz A, Schneider M et al. New Equations to Estimate GFR in Children with CKD. J Am Soc Nephrol 2009;20: 629–637
19. Finney H, Newman D, Thakkar H. et alReference ranges for plasma cystatin C and creatinine measurements in premature infants, neonates, and older children. Arch Dis Child 2000;82(1):71-75
Review
For citations:
Sitnikova V.P., Pashkova Y.V., Popova I.N. USING OF NEW MARKER OF GLOMERULAR FILTRATION RATE EVALUATION – CYSTATIN C IN PEDIATRIC PATIENTS. Nephrology (Saint-Petersburg). 2013;17(3):75-79. (In Russ.) https://doi.org/10.24884/1561-6274-2013-17-3-75-79
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