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SPIN PROBE METHOD USAGE IN KIDNEY DISEASES DIAGNOSTIC

https://doi.org/10.24884/1561-6274-2011-15-3-71-75

Abstract

New noninvasive express method of kidneys functional activity specification, based on research of minimal peripheral blood volume, was developed, tested and introduced in clinical practice. Spin probe parametrization method in blood serum of 177 patients with prior and secondary kidney diseases shown its advantage over traditional methodics in reference to nephron pathology incipient identification. Renal disfunction incipient diagnostic at patients with some systrmic diseases (diabetes, arterial hypertension, atherosclerosis, etc.) will provide nephroprotective (protective) therapy, decrease patient census with severe kidney failure and reduce expensive methods of extrarenal blood elimination employment.

About the Authors

V. S. PILOTOVICH
Белорусская медицинская академия последипломного образования
Russian Federation


V. S. FININ
Белорусский государственный университет
Russian Federation


References

1. Livshits VA, Marsh D. Fatty acid binding sites of serum albumin probed by non-linear spin-label EPR. Biochim Biophys Acta 2000; 1466; 350-360

2. Jalan R, Schnurr K, Mookerjee RP et al. Alterations in the functional capacity of albumin in patients with decompensated cirrhosis is associated with increased mortality. Hepatology 2009; 50(2): 555-564

3. Matthes G, Seibt G, Hersmann G et al. Albumin transport analysis of diiaierent collected and processed plasma products by electron spin resonance spectroscopy. Transfusion Apheresis Sci 2002; 27; 129-135

4. Финин ВС, Пилотович ВС. Изучение связывающей способности альбумина крови в норме и при заболеваниях. Известия НАНБ. Сер хим наук 2004; (2);109-110

5. Kragh-Hansen U, Chuang VTG, Otagiri M. 5. Practical aspects of the ligand-binding and enzymatic properties of human serum albumin Biol Pharm Bull 2002; 25(6); 695-704

6. Кузнецов АН. Метод спинового зонда. Основы и применение. Наука, М., 1976; 211


Review

For citations:


PILOTOVICH V.S., FININ V.S. SPIN PROBE METHOD USAGE IN KIDNEY DISEASES DIAGNOSTIC. Nephrology (Saint-Petersburg). 2011;15(3):71-75. (In Russ.) https://doi.org/10.24884/1561-6274-2011-15-3-71-75

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ISSN 1561-6274 (Print)
ISSN 2541-9439 (Online)