IMMUNOLOGICAL CHARACTERIZATION OF CHILDREN WITH CHRONIC GLOMERULONEPHRITIS ASSOCIATED WITH HEPATITIS VIRUSES AGAINST THE BACKGROUND OF HEMODIALYSIS

THE AIM of the work was to investigate immunological characteristics of children with chronic glomerulonephritis (CGN) associated with hepatitis viruses and treated with hemodialysis. PATIENTS AND METHODS. Eleven children (main group) with CGN against the background of chronic virus hepatitis (CVH) were examined. All of them were treated with hemodialysis. The age of the children was from 7 to 14 years. In 5 out of these children the hepatitis B virus was revealed, in 3 viruses of hepatitis B + C, in other 3 children the hepatitisdelta virus. A group of comparison consisted of 10 children of the same age with CGN without markers of the hepatitis virus and also treated with hemodialysis. The indices of cellular and humoral immunity were studied in all the patients. Serological investigations were made for the detection of hepatitis viruses. RESULTS. More pronounced impairments of the immunological status were noted in the main group of patients evidenced by a considerably decreased number of mature Tlymphocytes. Average indices of Thelpers were almost the same. The percentage of Tsuppressors was the least in this group of patients. The number of natural cells killers was of little difference in these groups. The percentage of zero lymphocytes was high. Changes in the humoral immunity were also more pronounces in the main group. CONCLUSION. The severity of the patients’ state was due to the decreased immunological reactions of organism that was associated with the virus antigen persistence. In the children with CGN against the background of virus hepatitis, as compared with the CGN patients without the hepatitis viruse markers, the changes in the indices of immunity were of one direction. But in the main group of patients the deficiency of T lymphocytes and Tsuppressors was more pronounced.

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