IMPAIRMENTS OF THE FUNCTIONAL STATE OF RATS’ KIDNEYS AFTER INJECTION OF CARBON TETRACHLORIDE

Abstract

THE AIM of the investigation was to study the functioning of the white rats’ kidneys in the acute period of damage of the liver with carbon tetrachloride. MATERIALS AND METHODS. White male rats with body mass 95120 g were given subcutaneous injections of carbon tetrachloride in dosage 0.5 ml per 100 g of body mass. The investigation of the renal function was performed in 24 hours after injection of CCl4 under conditions of water load (5% of body mass). RESULTS. It was found that injection of CCl4 resulted in a reliable diminution of the value of creatinin clearance, renal excretion of endogenous nitrites, nitrates and calcium. At the same time an increased excretion of osmotically active substances, protein and phosphates was registered. CONCLUSION. Injection of carbon tetrachloride results in reliable alterations of indices of renal functions. The results obtained allow a suggestion that the revealed declinations in renal functioning were mainly due to the impaired calcium transport at the nephron level which manifested itself as the increased renal excretion of protein, phosphates and osmotically active substances as well as the decreased concentration index of creatinin and are accompanied by a reduced glomerular filtration rate.