ANTIHYPERTENSIVE EFFECTIVENESS OF INTERVAL NORMOBARIC HYPOXYTHERAPY IN PATIENTS WITH CHRONIC GLOMERULONEPHRITIS AND ANGINA PECTORIS

Abstract

THE AIM of the investigation was to assess the antihypertensive effectiveness of interval normobaric hypoxytherapy (INBHT) in patients with combined pathology – chronic glomerulonephritis (CGN) and angina pectoris. PATIENTS AND METHODS. The investigation included 77 patients with combined pathology – angina on exertion and CGN. The first group consisted of 47 patients, who, according to recommendations of the European cardiological society (2006), were treated with nitrates, calcium channel blockers (CCB), antiaggregants , beta-adrenoblockers (BAB), statins, inhibitors of the angiotensin converting enzyme (by indications), diuretics (by indications) in combination with INBHT. The second group included 30 patients who were given only medicamentous therapy without INBHT. RESULTS. A comparison of the effects of the two therapeutic regimens on the values of arterial pressure has revealed more pronounced antihypertensive effects of the combination of medicamentous therapy with INBHT. The first group patients demonstrated less intensive decrease of heart rate than those treated without INBHT. The frequency of achieving the desired pressure level was 100% when medicamentous therapy was combines with INBHT, medicamentous therapy only – 77.7%. The rate of decreasing the systolic pressure proved to be higher when the medicamentous therapy was combined with INBHT, than without INBHT. Statistically reliable differences of systolic pressure were seen as earlyas in 3 hours after the beginning of the 24 hours monitoring of pressure. CONCLUSION. Combined therapy with INBHT allowed more effective control of arterial hypertension as compared with traditional medicamentous treatment of hypertensive syndrome.