Prediction of kidney tissue remodeling in view of small small diameter renal arteries structural changes

Abstract

THE AIM. Assessment of the relationship of renal tissue remodeling and small diameter arteries in patients with various forms of glomerulopathy. PATIENTS AND METHODS. The study included 30 patients with primary kidney disease. All investigated were performed kidney biopsy with the morphological assessment of structural changes in the kidney tissue (including morphometric analysis of interlobular artery) and morphological variant of glomerulonephritis. RESULTS. According to the results of the study revealed the presence of the direct proportional correlation between the restructuring of the interlobular artery walls and blood pressure value, as well as the severity of tubulointerstitial inflammation. The relationship between the decrease in lumen interlobular artery and different stages of glomerulosclerosis development (thickening of the glomerular capillary walls, fusion and obliteration of capillary loops, the formation of fibro-cellular crescents). Moreover, it was found that the fibrosis of interlobular arteries walls increases the risk of glomerulosclerosis. CONCLUSION. The findings testify that there is a single pathogenic process of remodeling of renal tissue and blood vessel walls of small diameter in patients with primary kidney diseases of different etiologies.