Nephroprotective effects of acizol on the background of cadmium sulphate intoxication

THE AIM of the study was to explore some of the pathogenic mechanisms of renal function disturbances during long-term administration of cadmium sulfate and preventive effects of Acyzol - an antihypoxant and antioxidant drug. MATERIALS AND METHODS. The work was carried out on 60 male Wistar rats, divided into three groups: intact; control with insolated cadmium sulfate administration at a dose of 0.1 mg / kg body weight; studied - with prophylactic Acyzol administration on the background of cadmium salts intake at the same dosage. The urine-generatory renal function, sodium and urea concentration in kidney tissue layers and Na+/K+-ATPase activity were studied. RESULTS. In animals with cadmium sulphate introduction the increase in the spontaneous six-hour urine output and sodium excretion, caused by reducing of water and cation reabsorption, marked proteinuria were observed. These changes correlated with the reduce in sodium and urea concentrations in all the layers of the kidneys, which also corresponded to the decrease in activity of the enzyme - Na+/K+-ATPase in kidney tissue layers. Acyzol injections to the animals on the background of cadmium intoxication led to the decrease of the severity of tubular reabsorption disorders, some recovery in activity of Na+/K+-ATPase, marked reduction of proteinuria. In the histological picture the differences between the groups with the isolated administration of cadmium salts and combined administration of cadmium sulfate and Acyzol were presented by the decrease of the severity of all pathological processes manifestations. The number of the tubules with preserved lumen was increased. CONCLUSION. Thus, the positive effect of Acyzol, which led to the decrease of the severity of the structural and functional changes in the renal nephrons tubular unit became evident. In the basis of Acyzol protective effect, obviously, lied its antihypoxic effect, which decreased the tubular hypoxic damage, caused by heavy metals

heavy metals, cadmium sulfate, toxic nephropathy, antihypoxants, Acyzol

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