LEADING ARTICLE
Current concepts of secondary hyperparathyroidism development and progression based on new data about pathophysiology and molecular mechanisms of phosphate-regulating systems interactions in terms of fibroblast growth factor 23 and Klotho role

REVIEWS AND LECTURES
ORIGINAL ARTICLES. CLINICAL INVESTIGATIONS
ORIGINAL ARTICLES. EXPERIMENTAL INVESTIGATION
THE AIM. Research of low-protein diet (LPD) with Ketosteril long-term administration effect on cardio-vascular system and rats values with experimentally decreasing of functional nephron quantity. MATERIAL AND METHODS. Work is completed on Wistar male rats with 5/6 nephrectomy (NE). During 4 months after NE one group of rats received standard diet (20.16% animal protein), another group - LPD with 10% Ketosteril. Control rats received either standard or low-protein diet. RESULTS. Administration of LPD with Ketosteril retarded experimental uremia progression, reduced phosphatemia, proteinuria, prevented triglyceride concentration increasing in serum. Experimental LPD cardioprotective effect included improving mean arterial pressure and prevention myocardium weight rising in rats with NE. RESULTS. Long-term usage of qualitatively and quantitatively balanced low- protein makes reno- and cardioprotective effects on animals with experimental kidney failure

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ISSN 2541-9439 (Online)